Dissolution rate of two fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) was analysed in presence/absence of three antacid formulations.Disintegration time and neutralisation capacity of antacid tablets were also checked.Variation in disintegration time indicated locinox verticlose 2 the importance of this classic carlectables - recent releases parameter, and allowed evaluation of the influence of postponed antacid-fluoroquinolone contact.
The results obtained in this study showed decreased dissolution rate of fluoroquinolone antibiotics from tablets in simultaneous presence of antacids, regardless of their type and neutralisation capacity.